Renal injury after muscle extract infusion in rats: Absence of toxicity with myoglobin

Summary A crude muscle extract infused into rats produced oliguria, a precipitous drop in total hemolytic complement, and in circulating white cell and platelets counts. A mild vaso-depressor effects was noted. These changes were not produced by myoglobin or saline infusion. Muscle constituents other than myoglobin are responsible for the systemic and renal nephrotoxic effects observed.Supported by Medical Research Council of Canada grant MA-1579.