Non-caspase proteases: triggers or amplifiers of apoptosis? |
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| Authors: | Karen Schrader Jisen Huai Lars Jöckel Carolin Oberle Christoph Borner |
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| Institution: | (1) Institute of Molecular Medicine and Cell Research (ZBMZ), Albert Ludwigs University Freiburg, Stefan Meier Str. 17, 79104 Freiburg, Germany;(2) Faculty of Biology, Albert Ludwigs University Freiburg, Freiburg, Germany;(3) Graduate School of Biology and Medicine (SGBM), Albert Ludwigs University Freiburg, Albertstr. 19a, 79104 Freiburg, Germany;(4) Centre for Biological Signaling Studies (Bioss), Albert Ludwigs University Freiburg, Albertstrasse 19, 79104 Freiburg, Germany;(5) Present address: Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, 76021 Karlsruhe, Germany; |
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| Abstract: | Caspases are the most important effectors of apoptosis, the major form of programmed cell death (PCD) in multicellular organisms. This is best reflected by the appearance of serious development defects in mice deficient for caspase-8, -9, and -3. Meanwhile, caspase-independent PCD, mediated by other proteases or signaling components has been described in numerous publications. Although we do not doubt that such cell death exists, we propose that it has evolved later during evolution and is most likely not designed to execute, but to amplify and speed-up caspase-dependent cell death. This review shall provide evidence for such a concept. |
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