| 组蛋白修饰组合模式研究进展 |
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| 引用本文： | 崔向军,李宏.组蛋白修饰组合模式研究进展[J].内蒙古大学学报(自然科学版),2012,43(1):101-111. |
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| 作者姓名： | 崔向军 李宏 |
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| 作者单位： | 1. 内蒙古大学物理科学与技术学院,呼和浩特010021;内蒙古科技大学生物工程与技术研究所,内蒙古包头014010
2. 内蒙古大学物理科学与技术学院,呼和浩特,010021 |
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| 基金项目： | 国家自然科学基金，国家教育部博士点基金，内蒙古自然科学基金，内蒙古科技大学创新基金 |
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| 摘 要： | 核小体是染色质的基本结构单位,核小体组蛋白N末端尾部可以发生甲基化、乙酰化等多种共价修饰.组蛋白密码假设多种组蛋白修饰以组合方式发挥作用.自组蛋白密码假设被提出后,组蛋白修饰组合模式成为表观遗传学领域的重要研究内容.在染色质免疫沉淀基因芯片和免疫沉淀高通量测序等相关实验数据的基础上,多种算法被用于研究组蛋白修饰的组合.文章介绍了组蛋白修饰的发生、位点、相关修饰酶以及生物学功能,对组蛋白修饰组合以及与基因表达关系的研究进行了总结,同时对组蛋白修饰组合模式一些适用的研究方法做了概述和分析.
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| 关 键 词： | 组蛋白修饰 组合 关联 因果关系 聚类 |
Advances on the Combinatorial Patterns of Histone Modifications |
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| CUI Xiang-Jun
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LI Hong.Advances on the Combinatorial Patterns of Histone Modifications[J].Acta Scientiarum Naturalium Universitatis Neimongol,2012,43(1):101-111. |
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| Authors: | CUI Xiang-Jun LI Hong |
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| Institution: | 1(1.School of Physical Science and Technology,Inner Mongolia University, Hohhot 010021,China; 2.Institute of Bioengineering and Technology,Inner Mongolia University of Science and Technology,Baotou 014010,China) |
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| Abstract: | Nucleosomes are the fundamental repeating units of all eukaryotic chromatins.The N-terminal tails of the core histones of nucleosomes are subject to various covalent modifications such as methylation,acetylation,et al.The ’histone code’ hypothesis suggests that multiple histone modifications act in a combinatorial fashion.After the ’histone code’ hypothesis was put forward,combinatorial patterns of histone modifications become an important research issue in the field of epigenetics.Based on experimental data of Chromatin immunoprecitation-chip and Chromatin immunoprecitation-seqencing,a multiple algorithm is used to study the combinations of histone modifications.The occurrence,sites,relevant modifying enzymes and biological functions of histone modifications are introduced.The research on the combinations among histone modifications and the relationships between the combinations and gene expression are summarized.Some applicable research methods on the combinatorial patterns of histone modifications are summarized and analyzed. |
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| Keywords: | histone modification combination correlation causal relationship clustering |
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