Induction of hemopoietic chimerism in the caprine fetus by intraperitoneal injection of fetal liver cells |
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| Authors: | R D Pearce D Kiehm D T Armstrong P B Little J W Callahan L R Klunder J T Clarke |
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| Institution: | Department of Pediatrics, University of Toronto, Ontario, Canada. |
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| Abstract: | Intraperitoneal injection of allogeneic liver cells from 43-day-old male fetuses into normal 60-day female goat fetuses resulted in persistent hemopoietic chimerism in surviving recipients without clinical evidence of graft-versus-host disease. Transplantation of normal fetal liver cells into preimmunocompetent goat fetuses affected with beta-D-mannosidosis may provide an alternative strategy for evaluating hemopoietic stem cell transplantation in the treatment of human lysosomal storage diseases. |
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