Modifications of female sex chromatin (Barr body) in rat neurons after reserpine administration |
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| Authors: | Androniki Beis Catherine Mytilineou Marietta R Issidorides |
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| Institution: | (1) Department of Zoology and Department of Psychiatry, University of Athens, 74 Vas. Sophias Avenue, Athens, Greece;(2) Present address: Department of Animal Physiology, University of Thessaloniki, Thessaloniki, Greece;(3) Present address: Department of Neurology, Mount Sinai School of Medicine, 100th & Fifth Avenue, 10029 New York, N.Y., USA |
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| Abstract: | Summary 3 groups of rats were sacrificed 30 min, 4 h and 24 h after reserpine (10 mg/kg, i. p.) injection. Toluidine blue stained sections showed that in the motor neurons of the spinal cord the drug, at 4 h, had induced a migration of the Barr body from the nucleolus to the nuclear membrane and an increase in its size and RNA concentration. From our findings we suggest that reserpine may have an activating role on X-linked genes.Supported by grant 0230-135 of the National Research Foundation of Greece. |
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