| 人参茎叶皂甙对哇巴因LD_(100)心功能和血流动力学的影响 |
| |
| 引用本文： | 陈延西,季晓玲,杨延秀,罗潜.人参茎叶皂甙对哇巴因LD_(100)心功能和血流动力学的影响[J].暨南大学学报,1988(2). |
| |
| 作者姓名： | 陈延西 季晓玲 杨延秀 罗潜 |
| |
| 作者单位： | 暨南理医药理教研室，暨南理医药理教研室，暨南理医药理教研室，暨南理医药理教研室 |
| |
| 摘 要： | 人参茎叶皂甙(Ginsensides of the stem and leaf of panax Ginseng, GSL)50毫克/公斤体重腹腔和静脉给药,均增加麻醉豚鼠哇巴因LD_(100)剂量(毒性降低);人参茎叶皂甙50毫克/公斤体重静脉注射,降低麻醉猫动脉压(AP)、左室内压(LVP)、心室内压上升最大速率(dp/dt max),心输出量(CO)有所增加,其他心功指标无明显影响。由于AP、LVP、dp/dt max降低,使TTI减少,提示心肌耗氧量降低,为临床治疗高血压、冠心病、心源性休克等循环系统疾病提供药理学基础。
|
| 关 键 词： | 人参茎叶皂甙 哇巴因LD_(100) 血流动力学 心脏后负荷 |
THE EFFECT OF GINSENOSIDES STEM LEAF ON THE OUABAIN LD_(100) CARDIAC FUNCTION AND HYMODYNEMICS |
| |
| Chen Yanxi Ji Xiaoling Yang Yanxiu Luo Qian.THE EFFECT OF GINSENOSIDES STEM LEAF ON THE OUABAIN LD_(100) CARDIAC FUNCTION AND HYMODYNEMICS[J].Journal of Jinan University(Natural Science & Medicine Edition),1988(2). |
| |
| Authors: | Chen Yanxi Ji Xiaoling Yang Yanxiu Luo Qian |
| |
| Institution: | Department of Pharmacology JNUMC |
| |
| Abstract: | The LD_(100) of ouabain was significantly increased when GSL 50mg/kg was given IP IV in 79 anesthetized guinea-pigs. In 5 anesthetized cats LVP, LVEDP, dp/dtmax of LVP, CO, ECG and AP were recorded on a RM6000 8-channel polygraph. The GSL 50mg/kg IV caused a significant decrease of AP, LVP, and dp/dtmax of LVP, but the CO is increased because the after load of heart is decreased. As a result of reduction of heart LVP, AP and tension-time index was reduced which suggests that the myocardial oxygen consumption is decreased. This is the pharmacological basis in the use of GSL for treatment of cardiac diseases. |
| |
| Keywords: | GSL=ginsenosides stem leaf LD_(100) of ouabain Cardiac performance Hemodynamics Cardiac output After load |
| 本文献已被 CNKI 等数据库收录！ |
