The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction |
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Authors: | S R Laviolette A A Grace |
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Institution: | (1) Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA |
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Abstract: | Cannabinoids represent one of the most widely used hallucinogenic drugs and induce profound alterations in sensory perception
and emotional processing. Similarly, the dopamine (DA) neurotransmitter system is critical for the central processing of emotion
and motivation. Functional disturbances in either of these neurotransmitter systems are well-established correlates of the
psychopathological symptoms and behavioral manifestations observed in addiction and schizophrenia. Increasing evidence from
the anatomical, pharmacological and behavioral neuroscience fields points to complex functional interactions between these
receptor systems at the anatomical, pharmacological and neural systems levels. An important question relates to whether these
systems act in an orchestrated manner to produce the emotional processing and sensory perception deficits underlying addiction
and schizophrenia. This review describes evidence for functional neural interactions between cannabinoid and DA receptor systems
and how disturbances in this neural circuitry may underlie the aberrant emotional learning and processing observed in disorders
such as addiction and schizophrenia.
Received 20 January 2006; received after revision 14 March 2006; accepted 29 March 2006 |
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Keywords: | Cannabinoid dopamine amygdala cortex addiction schizophrenia ventral tegmental area emotional processing associative learning |
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