3-Hydroxy-3-methylglutaric acid and experimental atherosclerosis in rats |
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Authors: | S Y K Yousufzai M Siddiqi |
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Institution: | (1) Department of Chemistry, Biochemistry Division, Aligarh Muslim University, 202001 Aligarh, (India) |
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Abstract: | Summary In rats 3-hydroxy-3-methylglutaric acid effectively counteracts the lipemic and atherosclerotic response of massive doses of vitamin D2. It regressed the formation of atheromatous arterial lesions. Furthermore the significant decrease in serum -lipoprotein levels on HMG treatment could be due to decrease in VLDL triglyceride and cholesterol levels.Acknowledgments. The authors are indebted to Dr.W. Drell, President, Calbiochem, San Diego, California, USA, for generous gift of HMG and Lady Tata Memorial Trust, India, for providing financial assistance to one of us (S.Y.K.Y.). |
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