Inhibitory effect of halocyamine,an antimicrobial substance from ascidian hemocytes,on the growth of fish viruses and marine bacteria |
| |
Authors: | K Azumi M Yoshimizu S Suzuki Y Ezura H Yokosawa |
| |
Institution: | (1) Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, 060 Sapporo, (Japan);(2) Department of Food Science and Technology, Faculty of Fisheries, Hokkaido University, 041 Hakodate, (Japan) |
| |
Abstract: | Summary Halocyamine A, an antimicrobial substance isolated from hemocytes of the solitary ascidianHalocynthia roretzi, inhibited in vitro the growth of fish RNA viruses (infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus). Pretreatment of RNA virus with halocyamine A reduced the infectivity of the virus toward host cells. The growth of marine bacteria,Achromobacter aquamarinus andPseudomonas perfectomarinus, was also inhibited by halocyamine A but that ofAlteromonas putrefaciens andVibrio anguillarum was not. These results suggest that halocyamine may have a role in the defense mechanisms ofH. roretzi against marine viruses and bacteria. |
| |
Keywords: | Halocyamine antiviral substance antibacterial substance ascidian hemocyte |
本文献已被 SpringerLink 等数据库收录! |
|