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A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia |
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| Authors: | Di Bernardo Maria Chiara Crowther-Swanepoel Dalemari Broderick Peter Webb Emily Sellick Gabrielle Wild Ruth Sullivan Kate Vijayakrishnan Jayaram Wang Yufei Pittman Alan M Sunter Nicola J Hall Andrew G Dyer Martin J S Matutes Estella Dearden Claire Mainou-Fowler Tryfonia Jackson Graham H Summerfield Geoffrey Harris Robert J Pettitt Andrew R Hillmen Peter Allsup David J Bailey James R Pratt Guy Pepper Chris Fegan Chris Allan James M Catovsky Daniel Houlston Richard S |
| Institution: | Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK. |
| Abstract: | We conducted a genome-wide association study of 299,983 tagging SNPs for chronic lymphocytic leukemia (CLL) and performed validation in two additional series totaling 1,529 cases and 3,115 controls. We identified six previously unreported CLL risk loci at 2q13 (rs17483466; P = 2.36 x 10(-10)), 2q37.1 (rs13397985, SP140; P = 5.40 x 10(-10)), 6p25.3 (rs872071, IRF4; P = 1.91 x 10(-20)), 11q24.1 (rs735665; P = 3.78 x 10(-12)), 15q23 (rs7176508; P = 4.54 x 10(-12)) and 19q13.32 (rs11083846, PRKD2; P = 3.96 x 10(-9)). These data provide the first evidence for the existence of common, low-penetrance susceptibility to a hematological malignancy and new insights into disease causation in CLL. |
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