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Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12 |
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| Authors: | Sun Jielin Zheng Siqun Lilly Wiklund Fredrik Isaacs Sarah D Purcell Lina D Gao Zhengrong Hsu Fang-Chi Kim Seong-Tae Liu Wennuan Zhu Yi Stattin Pär Adami Hans-Olov Wiley Kathleen E Dimitrov Latchezar Sun Jishan Li Tao Turner Aubrey R Adams Tamara S Adolfsson Jan Johansson Jan-Erik Lowey James Trock Bruce J Partin Alan W Walsh Patrick C Trent Jeffrey M Duggan David Carpten John Chang Bao-Li Grönberg Henrik Isaacs William B Xu Jianfeng |
| Affiliation: | Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. |
| Abstract: | We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP. |
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