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Study of β—amyloid adsorption and aggregation on graphite by STM and AFM
作者姓名:WANGZhigang WANLijun ZHOUChungqing FANGXiaohong WANGChen BAIChunli
作者单位:InstituteofChemistry,ChineseAcademyofSciences,Beijing100080,China
基金项目:国家自然科学基金,中国科学院资助项目 
摘    要:The scanning tunneling microscopy(STM) and the atomic force microscopy(AMF) have been applied to the direct study of the adsorption and aggregation of β-amyloid(1-42)(Aβ42)on the hydrophobic graphite surface.It was found that Aβ42 were preferentially adsorbed on graphite defects such as the edges.Aβ42 peptides self-assembled into intermediate protofibrils,which in turn self-associated to form fibrils.Usually,two or more fibrils intertwined to form the helical structure.These results will provide an important clue to studying the aggregation process of β-amyloid.

关 键 词:β-环糊精 石墨 吸附 聚集 扫描隧道显微镜 原子力显微镜 早老性痴呆 药物载体
收稿时间:2002-06-13
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