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| 补阳还五汤对脊髓损伤大鼠体重及后肢运动功能的影响 | |
| 引用本文： | 张继平,侯剑萍,符名赟,林爱华,王志彬,李蜀光.补阳还五汤对脊髓损伤大鼠体重及后肢运动功能的影响[J].佛山科学技术学院学报(自然科学版),2009,27(1):78-82. |
| 作者姓名： | 张继平 侯剑萍 符名赟 林爱华 王志彬 李蜀光 |
| 作者单位： | 1. 佛山市第二人民医院,广东,佛山,528000 2. 广州市白云区第一人民医院,广东,广州510410 3. 佛山市中医院,广东,佛山,528000 |
| 基金项目： | 广东省科技厅科技攻关项目，广东省中医药局课题 |
| 摘 要： | 目的探讨补阳还五汤对脊髓损伤大鼠体重及后肢运动功能影响与其神经保护作用的关系。方法采用Allen’s打击法制作中度SCI模型,应用SPF级Wistar大鼠,随机分为4组：正常组和3个模型组,即模型空白组、BYHWD组、金纳多组,每组16只大鼠。模型组大鼠分别给予蒸馏水、BYHWD、金纳多水溶液,正常组给予蒸馏水,分别于造模前即0 d、造模后3 d、1 w、2 w、3 w,称量大鼠体重,并进行后肢运动功能评价,灌胃治疗2 w后,结束实验。结果SCI模型大鼠于造模后3 d体重及后肢运动功能均明显降低,灌胃治疗后,模型空白组大鼠体重缓慢增加,但后肢运动功能无明显改善;BYHWD组及金纳多组大鼠体重及后肢运动功能均有显著改善,且BYHWD组改善效果更明显,与金纳多组比较差异有显著性。结论BYHWD通过保护SCI大鼠脊髓组织,显著改善大鼠后肢运动功能,增加大鼠体重,为其治疗中医＂痿证＂提供了新的实验依据。 |
| 关 键 词： | 补阳还五汤 大鼠 脊髓损伤 体重 后肢运动功能 |
Influence of buyanghuanwu decoction on the weight and hindlimb motor function of rats with spinal cord injury |
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| ZHANG Ji-ping,HOU Jian-ping,FU Ming-bin,LIN Ai-hua,WANG Zhi-bin,LI Shu-guang.Influence of buyanghuanwu decoction on the weight and hindlimb motor function of rats with spinal cord injury[J].Journal of Foshan University(Natural Science Edition),2009,27(1):78-82. | |
| Authors: | ZHANG Ji-ping HOU Jian-ping FU Ming-bin LIN Ai-hua WANG Zhi-bin LI Shu-guang |
| Institution: | 1.Department of Science and Education;Foshan Second People's Hospital;Foshan 528000;China;2.Baiyun First People's Hospital;Guangzhou 510410;3.Foshan Chinese Medicine Hospital;China |
| Abstract: | Objective To discuss the influence of Buyanghuanwu Decoction on the weight and the hindlimb motor function of rats with spinal cord injury,and its action relation with the neuroprotective effect.Methods SPF Wistar Rats were divided randomly into Normal group(Group A) and Model groups,which were Model control group(Group B),Buyanghuanwu decoction group(Group C) and Ginaton group(Group D) respectively.There were 16 rats in each group.Experimental SCI mode was built based on Allen's method.Rats in Normal group... |
| Keywords: | buyanghuanwu decoction rat spinal cord injury weight hindlimb motor function |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |