Inhibition of sarcolemmal Na,K, Mg ATPase from the guinea pig heart is not compatible with a homogeneous population of non-interacting ouabain receptors |
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| Authors: | F Ebner G Schönsteiner |
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| Institution: | (1) Institut für Pharmakologie und Toxikologie der Technischen Universität München, Biedersteiner Strasse 29, D-8000 München 40, (Federal Republic of Germany) |
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| Abstract: | Summary The inhibition of sarcolemmal Na, K, Mg ATPase from the guinea pig heart by ouabain was evaluated with a coupled enzyme assay. Models of negative cooperativity and of two independent receptors fitted the inhibition data equally well. The analysis was not compatible with a homogeneous population of non-interacting ouabain receptors.Acknowledgments. The technical assistance of P. Mayr and G. Ruhland is gratefully acknowledged. |
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| Keywords: | Na K Mg ATPase ouabain negative cooperativity multi-site ouabain binding |
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