| 海洛因对小脑皮质Bax表达的影响 |
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| 引用本文： | 谢明仁,李作平,俞发荣,连秀珍.海洛因对小脑皮质Bax表达的影响[J].实验动物科学,2013(5):6-8. |
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| 作者姓名： | 谢明仁 李作平 俞发荣 连秀珍 |
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| 作者单位： | 甘肃政法学院甘肃省证据科学技术研究与应用重点实验室,兰州730070 |
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| 基金项目： | 甘肃省自然科学基金项目（No.1010RJZA145）;甘肃省高校学科带头人扶持项目计划项目,甘教字[2011]23号;甘肃省青年科技基金计划项目（No.1208RJYA098）;甘肃政法学院科研资助重点项目（No.GZF2011XZDLW29）;甘肃政法学院科研资助青年项目（No.050204）;甘肃省证据科学技术研究与应用重点实验室科技计划项目（ZDSYS-Y17） |
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| 摘 要： | 目的 探索海洛因对小脑皮质Bax蛋白（bcl-x protein Bax）表达的影响.方法 肌肉注射海洛因,建立成瘾大鼠模型,用免疫组化方法检测小脑细胞Bax的表达.结果 连续给大鼠注射海洛因7d后,大鼠出现明显的戒断症状;小脑细胞中Bax表达阳性细胞比对照组明显增多,与对照组比有显著性差异（P＜0.01）.结论 海洛因具有诱导Bax基因表达、损伤脑组织细胞的作用.
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| 关 键 词： | 海洛因 Bax 小脑皮质 大鼠 |
Effect of Heroin on Bax Expression in Cerebellar Cortex in Rat |
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| XIE Ming-ren,LI Zuo-ping,YU Fa-rong,LIAN Xiu-zhen.Effect of Heroin on Bax Expression in Cerebellar Cortex in Rat[J].Shiyan Dongwu Kexue,2013(5):6-8. |
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| Authors: | XIE Ming-ren LI Zuo-ping YU Fa-rong LIAN Xiu-zhen |
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| Institution: | 1.Gansu Institute of Political Science and Law, Key Laboratory of Evidence of Science and Technology Research and Application, Gansu Province, Lanzhou 730070, China;) |
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| Abstract: | Objective To study the effects of heroin on the Bax expression of cerebellar cortex in rats.Method Addiction model was copied by intramuscular injection of heroin.Bax expression of cerebellar cortex was detected by immunohistochemistry methods.Result Rats had significant withdrawal symptoms after continuous injection of heroin for 7 days; the Bax-positive expression cells in cerebellar cortex of rats were increased significantly than that of the control group （P ＜ 0.01）.Conclusion Heroin has the effect of inducing Bax gene expression and damaged brain cells. |
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| Keywords: | heroin Bax cerebellar cortex rat |
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