TreeOfTrees Method to Evaluate the Congruence Between Gene Trees |
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Authors: | Pierre Darlu Alain Gu��noche |
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Institution: | 1. UMR 7206, MNHN, CNRS, 61 rue Buffon, 75005, Paris, France 2. UMR 6206, CNRS, 163, avenue de Luminy, 13009, Marseille, France
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Abstract: | A new method, TreeOfTrees, is proposed to compare X-tree structures obtained from several sets of aligned gene sequences of
the same taxa. Its aim is to detect genes or sets of genes having different evolutionary histories. The comparison between
sets of trees is based on several tree metrics, leading to a unique tree labelled by the gene trees. The robustness values
of its edges are estimated by bootstrapping and consensus procedures that allow detecting subsets of genes having differently
evolved. Simulations are performed under various evolutionary conditions to test the efficiency of the method and an application
on real data is described. Tests of arboricity and various consensus algorithms are also discussed. A corresponding software
package is available. |
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Keywords: | |
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