基于复合物结构和网络拓扑特性的关键蛋白质识别算法

关键蛋白质的识别有助于从分子水平上理解生命的活动过程,然而仅从拓扑特性角度来识别的关键蛋白质不够精准,因此为了提高识别准确率,结合复合物信息提出了确定蛋白质关键性的指标模型EIC,该模型是基于蛋白质复合物内的局部中心性特性以及网络的全局信息特性来考虑.使用DIP和MIPS两种蛋白质相互作用(PPI)网络作为实验数据集,...

Identification of essential proteins based on protein complex and topology properties

The identification of essential proteins is helpful to understand the process of life at the molecular level, thus the identification of essential proteins has gradually become an important research work. However, the identification of essential proteins that only focused on the topological characteristics is not accurate enough. To improve the recognition accuracy, a new method EIC was proposed, which integrated the local central information and global topological features of protein complex for identifying essential proteins. Different Protein-Protein Interaction (PPI) networks of DIP and MIPS were used as materials.Some experiments of different assessment method were used including precise-recall curves and jackknife methodology.By comparing the proposed method with the existing methods such as DC, BC, EC, SC, LAC, NC and the recent method UC, the ability of recognizing essential proteins by the proposed method EIC is more effective, in that it may enhance the accuracy for identifying essential proteins.