Influence of castration and testosterone replacement on hypothalamic tyrosine hydroxylase activity in the rat |
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Authors: | C. W. Beattie Margaret M. Martin |
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Affiliation: | (1) Endocrinology Section, Wyeth Laboratories, Research Division, Box 8299, 19101 Philadelphia, Pennsylvania, USA |
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Abstract: | ![]() Summary Hypothalamic tyrosine hydroxylase (TH) activity of castrate rats is modulated by testosterone propionate (TP) in vivo. Kinetic studies revealed that bothVmax andKm were virtually unaltered for substrate tyrosine in the presence of an excess of DMPH4 cofactor. TP replacement to castrate rats increased theKm for added DMPH4 cofactor, whileVmax decreased. These results suggest that TP decreases TH activity of castrate rats by inhibiting the enzymereduced pteridine cofactor complex. |
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