Hypothalamo-hypophyseal-gonadal function in the rat following administration of the novel and selective D-1 agonist CY 208-243 |
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| Authors: | R A Siegel M Markó |
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| Institution: | (1) Preclinical Research, Pharma Division, Sandoz AG, CH-4002 Basel, (Switzerland);(2) Project Management, Sandoz-Wander Pharma AG, PO Box 2196, CH-3001 Bern |
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| Abstract: | Summary The effects of the novel and selective dopamine D-1 agonist CY 208-243 on the rat hypothalamo-hypophyseal-gonadal (HHG) axis were studied. CY 208-243 did not modify the concentration of luteinizing hormone (LH) in serum from female or male rats, and had no effect upon opiate antagonist-induced stimulation of LH secretion in male rats. CY 208-243 did not inhibit ovulation in cycling female rats. Thus, D-1 receptor activation by systemic drug administration does not alter HHG function in rats. |
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| Keywords: | Hypothalamo-hypophyseal-gonadal axis dopamine D-1 neurotransmission |
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