Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid inRhodopseudomonas spheroides |
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| Authors: | R Couso M Dimitrijewits de Albani G A Locascio H A Tigier |
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| Institution: | (1) Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Ciudad Universitaria, Buenos Aires, (Argentina);(2) Comisión Nacional de la Energía Atómica, Buenos Aires, (Argentina);(3) Departamento de Ciencias Biológicas, Campus Universitario, Universidad Nacional de Río Cuarto, 5800 Río Cuarto, Córdoba, Argentina;(4) Present address: Instituto de Investigaciones Bioquímicas, Obligado 2490, 1428 Buenos Aires, Argentina |
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| Abstract: | Summary Porphyrin biosynthesis from 4,5-dioxovaleric acid was studied in cell suspensions ofR. spheroides. The experiments show that 4,5-dioxovaleric acid is a far precursor of porphyrins through  amino laevulinic acid formation in a transamination reaction involving also 1-alanine. It differs radically from the classical aminolaevulinic acid synthesis using glycine and succinyl CoA as substrates.Acknowledgments: The authors are indebted to Dr Rodolfo García for helpful discussions and criticisms. Special thanks are given to Dr Aldo Mitta and other members of the  Comisión Nacional de la Energía Atómica for their continuous help and support and for using their facilities in order to synthetise DVA. |
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