Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor |
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| Authors: | F Ishikawa K Miyazono U Hellman H Drexler C Wernstedt K Hagiwara K Usuki F Takaku W Risau C H Heldin |
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| Institution: | Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan. |
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| Abstract: | Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo. |
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