Intracellular trafficking of AMPA receptors in synaptic plasticity |
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Authors: | Man H Y Ju W Ahmadian G Wang Y T |
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Institution: | (1) Research Institute of Hospital for Sick Children, Department of Laboratory Medicine and Pathobiology, University of Toronto, 555 University Ave., Toronto (Canada M5G 1X8), CA |
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Abstract: | Modification of ligand-gated receptor function at the postsynaptic domain is one of the most important mechanisms by which
the efficacy of synaptic transmission in the nervous system is regulated. Traditionally, these types of modifications have
been thought to be achieved mainly by altering the channel-gating properties or conductance of the receptors. However, recent
evidence suggests that AMPA (α-amino-3-hydroxyl-5-methyl-4-isoxayolepropionic acid)-type ligand-gated glutamate receptors are continuously recycling between
the plasma membrane and the intracellular compartments via vesicle-mediated plasma membrane insertion and clathrin-dependent
endocytosis. Regulation of either receptor insertion or endocytosis results in a rapid change in the number of these receptors
expressed on the plasma membrane surface and in the receptor-mediated responses, thereby playing an important role in mediating
certain forms of synaptic plasticity. Thus, controlling the number of postsynaptic receptors by regulating the intracellular
trafficking and plasma membrane expression of the postsynaptic receptors may be a common and important mechanism of synaptic
plasticity in the mammalian central nervous system. |
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Keywords: | , Exocytosis, endocytosis, protein trafficking, AMPA receptor, synaptic plasticity, |
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