Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. |
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| Authors: | J H Wang Y W Yan T P Garrett J H Liu D W Rodgers R L Garlick G E Tarr Y Husain E L Reinherz S C Harrison |
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| Institution: | Harvard University, Department of Biochemistry and Molecular Biology, Cambridge, Massachusetts. |
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| Abstract: | The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface. |
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