| 微囊藻毒素对小鼠肝脏抗氧化系统的影响 |
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| 引用本文： | 张榜军,李效宇.微囊藻毒素对小鼠肝脏抗氧化系统的影响[J].河南师范大学学报(自然科学版),2007,35(3):143-145. |
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| 作者姓名： | 张榜军 李效宇 |
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| 作者单位： | 河南师范大学,生命科学学院,河南,新乡,453007 |
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| 基金项目： | 河南省高校杰出科研创新人才工程项目
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河南省动物学省级重点学科经费资助项目 |
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| 摘 要： | 通过灌胃染毒的方法研究了微囊藻毒素对小鼠抗氧化系统的毒性.结果显示,超氧化物歧化酶活性在第4周升高,过氧化氢酶活性在第3周和第4周下降,表明微囊藻毒素处理后导致H2O2积累,使得氧化损伤加强.谷胱甘肽含量从第2周开始出现明显下降.谷胱甘肽-S-转移酶活性在第4周时发生显著性升高,提示微囊藻毒素和谷胱甘肽结合的速率增高,从而加快了肝组织对微囊藻毒素的清除.本实验结果说明抗氧化系统在微囊藻毒素的解毒方面起到了十分重要的作用.
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| 关 键 词： | 微囊藻毒素 小鼠 抗氧化系统 毒性 |
| 文章编号： | 1000-2367（2007）03-0143-03 |
| 修稿时间： | 2006-11-26 |
Toxicity of Microcystins on Antioxidant System in Mouse Liver |
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| ZHANG Bang-jun,LI Xiao-yu.Toxicity of Microcystins on Antioxidant System in Mouse Liver[J].Journal of Henan Normal University(Natural Science),2007,35(3):143-145. |
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| Authors: | ZHANG Bang-jun LI Xiao-yu |
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| Institution: | College of Life Science, Henan Normal University, Xinxiang 453007, China |
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| Abstract: | The toxicity of microcystins on the antioxidant system in mouse liver was investigated.In the present paper,microcystins were administered by gavage to mice at a daily dose of 0.2 mg microcystins·kg-1 body weight for 28 days.The activities of superoxide dismutase increased significantly after 28 days of exposure while catalase decreased at the terminal of exposure.After 7 days,the content of glutathione in liver decreased as compared with control.Glutathione S-transferase activity augmented in treated group compared with the control after 28 days of exposure,suggesting a higher conjugation rate of the toxins with glutathione.These findings suggest that antioxidant system might play an important role in microcystins detoxication in mice. |
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| Keywords: | microcystins mice antioxidant system toxicity |
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