| 正链RNA病毒基因组的复制 |
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| 引用本文： | 王雨净,张楚瑜,肖明.正链RNA病毒基因组的复制[J].河南师范大学学报(自然科学版),2007,35(3):126-131. |
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| 作者姓名： | 王雨净 张楚瑜 肖明 |
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| 作者单位： | 1. 上海师范大学,生命与环境科学学院,生物系,上海,200234
2. 武汉大学,生命科学学院,病毒研究所,武汉,430070 |
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| 摘 要： | 许多正链RNA病毒是严重危害人类健康的病原体,是造成经济植物动物死亡的致病因子.正链RNA病毒的基因组为正链RNA,其复制酶是依赖RNA的RNA聚合酶,非编码区是病毒基因组复制的主要调控位点,3’非编码区是复制酶的第一结合位点,正链RNA病毒基因组大多可能按copy-back模型进行复制.瘟病毒基因组的复制过程出现正链复制本的数量大于负链复制本的数量,这可能是以RF中间体的负链RNA为模板、正链RNA被置换的形式进行复制的结果.本文概述了HCV细胞培养系统的研究进展.
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| 关 键 词： | 正链RNA病毒 依赖RNA的RNA聚合酶 非编码区 |
| 文章编号： | 1000-2367（2007）03-0126-06 |
| 修稿时间： | 2006-12-20 |
Replication of Plus-strand RNA Viral Genome |
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| WANG Yu-jing,ZHANG Chu-yu,XIAO Ming.Replication of Plus-strand RNA Viral Genome[J].Journal of Henan Normal University(Natural Science),2007,35(3):126-131. |
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| Authors: | WANG Yu-jing ZHANG Chu-yu XIAO Ming |
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| Institution: | 1, Biology Department, College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234,China 2. Institute of Virology, College of Life Sciences, Wuhan University, Wuhan 430072,China |
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| Abstract: | Many plus-strand RNA viruses are the causative agents of some highly contagious diseases in human,animal and plant.The genome for these viruses is plus-strand RNA.The RNA-dependent RNA polymerase(RdRp) is the viral replicase.The non-coding region is the important regulatory site,and the 3' uncoding region is essential to initiation of viral replication.The replication of plus-strand RNA viral genome may occur by copy-back mechanism.The number of plus-strand RNA replica is more than that of minus-strand RNA replica in the Pestivirus genome replication,the reason may result from the replication mechanism in which the plus-strand RNA is replaced with the minus-strand RNA template of the RF intermediate. |
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| Keywords: | plus-strand RNA viruses RNA-dependent RNA polymerase non-coding region |
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