| 新发现和正在研究中的细胞凋亡蛋白抑制剂(综述) |
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| 引用本文： | 杨昌山. 新发现和正在研究中的细胞凋亡蛋白抑制剂(综述)[J]. 暨南大学学报(自然科学与医学版), 2002, 23(4): 20-23 |
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| 作者姓名： | 杨昌山 |
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| 作者单位： | 暨南大学医学院病理生理学教研室,广东,广州,510632 |
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| 摘 要： | 自从杆状病毒中分离出凋亡蛋白抑制剂 (inhibitorofapoptosisproteins ,IAPs)后 ,发现的凋亡蛋白抑制剂的种类和数量逐渐增多。迄今为止 ,在人体新发现的IAPs有HIAP - 1(humanIAP -1)、HIAP - 2 (humanIAP - 2 )、XIAP(Xchromosome -likedIAP)、ML -IAP(melanocytesIAP)、Survivin和Livin等。对IAPs的发现、定位、结构、分布和作用等方面的研究进展进行介绍
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| 关 键 词： | 凋亡蛋白抑制剂 生存素 细胞凋亡 |
| 文章编号： | 1000-9965(2002)04-0020-04 |
| 修稿时间： | 2001-12-19 |
The inhibitor of apoptosis proteins in research and newly discovered(A review) |
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| YANG Chang-shan. The inhibitor of apoptosis proteins in research and newly discovered(A review)[J]. Journal of Jinan University(Natural Science & Medicine Edition), 2002, 23(4): 20-23 |
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| Authors: | YANG Chang-shan |
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| Abstract: | There are many mechanisms regulating apoptosis. With the development of research in the inhibitor of apoptosis proteins(IAPs), which is one of effective inhibitor to suppress cell death induced by various stimuli, the family of IAPs have become larger and larger, since the first IAP was identified in baculovirus. Up to now, some human IAPs have been found, such as NAIP, HIAP-1, HIAP-2, XIAP, ML-IAP, surviving and Livin. It is necessary to introduce the detecting, location, structure, distribution and role of IAPs. So, the review is just to clarify the latest research progress. |
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| Keywords: | inhibitor of apoptosis proteins survivin apoptosis |
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