A facile one-step synthesis of cysteinyldopas using mushroom tyrosinase |
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Authors: | S. Ito G. Prota |
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Affiliation: | (1) Stazione Zoologica, Napoli and Istituto di Chimica Organica dell'Università, Via Mezzocannone 16, I-80134 Napoli, (Italy) |
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Abstract: | Summary A convenient one-step procedure, based upon the tyrosinase co-oxidation of dopa and cysteine, is reported for the synthesis of 5-S-cysteinyldopa (I) in 74% yield. Secondary products of the reaction turned out to be 2-S-cysteinyldopa (II, 14%), 2,5-S, S-dicysteinyldopa (IV, 5%), and the hitherto unknown 6-S-cysteinyldopa (III, 1%).The generic term cysteinyldopa is proposed to designate the various cotechol amino-acids arising from addition of cysteine to dopaquinone.This work was supported in part by a grant from Consiglio Nazionale delle Ricerche, Roma. |
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