Nitric oxide-related pancreatic endocrine responses to hyperglycaemia in the conscious calf |
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| Authors: | A. V. Edwards M. A. Ghatei S. R. Bloom |
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| Affiliation: | (1) Physiological Laboratory, University of Cambridge, Downing Street, CB2 3EG Cambridge, (UK);(2) Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, W12 ONN London, (UK) |
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| Abstract: | Mean plasma insulin concentration was reduced and mean plasma glucose concentration increased following the administration of N-nitro-L-arginine methyl ester (L-NAME; 100  mol kg–1 i.a.) in conscious calves given continuous infusions of exogenous glucose (30–60 mol min–1 kg–1 i.v.). It is concluded that the rise in plasma insulin concentration which occurs in these animals in response to glucose is mediated, at least in part, by a nitric oxide-related factor (NOx). |
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| Keywords: | Nitric oxide insulin endocrine pancreas L-NAME |
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