| 低剂量氟化物对新生大鼠成骨细胞增殖的影响 |
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| 引用本文： | 丁文鹏,沈立明,何智慧.低剂量氟化物对新生大鼠成骨细胞增殖的影响[J].湖南文理学院学报(自然科学版),2012(3):46-49. |
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| 作者姓名： | 丁文鹏 沈立明 何智慧 |
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| 作者单位： | 深圳大学生命科学学院;深圳市库源生物科技有限公司 |
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| 摘 要： | 氟是人体内重要的微量元素之一,低剂量的氟化物作用成骨细胞与骨代谢关系密切.成骨细胞活跃和骨转换加速是氟骨症的重要特征.研究了氟化物对成骨细胞增殖以及细胞分裂周期的影响,证实了低剂量的氟化物(2 mg/L)能引起体外培养的成骨细胞的细胞增殖并增加细胞分裂增殖的代数.
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| 关 键 词： | 氟化物 大鼠 成骨细胞 增殖 |
The influence of low dose of fluoride on the proliferation of neonatal rat osteoblasts |
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| DING Wen-peng,SHEN Li-ming,HE Zhi-hui.The influence of low dose of fluoride on the proliferation of neonatal rat osteoblasts[J].Journal of Hunan University of Arts and Science:Natural Science Edition,2012(3):46-49. |
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| Authors: | DING Wen-peng SHEN Li-ming HE Zhi-hui |
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| Institution: | 1.School of Life Sciences,Shenzhen University,Shenzhen 518000,China;2.Shenzhen Coolrun Life Science,Shenzhen 518000,China) |
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| Abstract: | Fluorine is one of the important trace elements in the human body,and closely related to bone metabolism.Osteoblast cell activity and bone turnover acceleration is an important characteristic of skeletal fluorosis.In this work,the impact of fluorinecompounds on osteoblast cell proliferation and cell division cycle was studied with low doses of fluoride.It was confirmed that low doses of fluoride(2 mg/L) can cause osteoblast cell proliferation in vitro and accelerate the proliferation of cell division algebra. |
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| Keywords: | Fluoride Rats Osteoblasts Proliferation |
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