八种天然黄酮类化合物的抗氧化构效关系

采用H2O2－CTMAB－Luminol化学发光体系和Fe^2＋诱发脂蛋白PUFA过氧化比色体系，研究了八种高纯度的天然黄酮类化合物清除H2O2、LO和LOO的构效关系。结果表明，这八种天然黄酮类化合物都能 有效地清除H2O2、LO和LOO。根据其清除作用和化学结构分析，得出如下结论：B环上羟基是清除H2O2、LO和LOO的主要活性基团，A环上羟基是清除H2O2、LO和LOO的重要基团，并且B环上羟基相邻清除作用就大大增强；糖甙对清除H2O2、LO和LOO也有贡献。

Relationship between Structure and Activity of Eight Natural Flavonoids Against Oxidation

Relationship between structure and activity of eight pure and natural flavonoids scavenging H 2O 2 ?LO .and LOO .were studied by chemiluminescence system and Fe 2+ inducing lipoprotein PUFA peroxidation colorimetric system. The results showed that the eight flavonoids can effectively scavenge H 2O 2LO .and LOO . . According to analysis for their scavenging effects and chemical structures we obtained the conclusions as follow: Hydroxyl groups in the B ring are main active groups scavenging H 2O 2LO . and LOO . . Hydroxyl groups in the A ring are important groups scavenging H 2O 2LO .and LOO . . When hydroxyl groups in the B ring adjoin, the scavenging effects can markedly increase. The glucosides also contributed to scavenge H 2O 2LO .and LOO ..