Radiation-released histamine in the rhesus monkey as modified by mast-cell depletion and antihistamine |
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| Authors: | T. F. Doyle T. A. Strike |
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| Affiliation: | (1) Neurobiology Department, Armed Forces Radiobiology Research Institute, 20014 Bethesda, Maryland, USA;(2) Present address: Baltimore Cancer Research Center, Division of Cancer Treatment, National Cancer Institute, 20014 Bethesda, Maryland, USA |
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| Abstract: | ![]()
Summary 4000 rads of mixed gamma neutron radiation administered to rhesus monkeys released a significant amount of histamine into their circulation. When the monkeys were treated with a mast-cell histamine depleter (compound 48/80) for 4 days and then irradiated, no increase in circulating histamine was seen. When 48/80 was given 20 min after irradiation, only a slight increase in histamine was seen, indicating that 4000 rads had released most of the mast-cell histamine. |
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