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| 5-氟尿嘧啶壳聚糖纳米微球的制备及表征 | |
| 引用本文： | 刘秋香,曾林涛,梁艳,覃彩芹.5-氟尿嘧啶壳聚糖纳米微球的制备及表征[J].孝感学院学报,2007,27(3):5-8. |
| 作者姓名： | 刘秋香 曾林涛 梁艳 覃彩芹 |
| 作者单位： | 1. 中国地质大学,材料科学与化学工程学院,湖北,武汉,430074;孝感学院,化学系,湖北,孝感,432000 2. 孝感学院,化学系,湖北,孝感,432000 3. 中国地质大学,材料科学与化学工程学院,湖北,武汉,430074 |
| 摘 要： | 壳聚糖(CS)作载体,与三聚磷酸钠(TPP)和5-氟尿嘧啶(5-Fu)发生离子交联反应,制备具有缓释效能的5-氟尿嘧啶壳聚糖纳米微球,并以微球载药量、颗粒大小为指标设计优化了其制备方法,考察不同因数水平对微球的载药量的影响。用傅立叶红外光谱表征了其结构,用激光散射粒径仪测得微球的平均粒径为143~212 nm。氟尿嘧啶壳聚糖微球最大载药量为48.3%,在pH 7.1磷酸盐缓冲溶液中对氟尿嘧啶的缓释作用明显,释放周期较长,药物含量越大,药物从微球中释放出来的速率越快,可作为靶向药物控释体系。 |
| 关 键 词： | 氟尿嘧啶 壳聚糖 离子交联法 纳米微球 缓释 |
| 文章编号： | 1671-2544（2007）03-0005-04 |
| 收稿时间： | 2007-04-04 |
| 修稿时间： | 2007年4月4日 |
Preparation and Characterization of Chitosan-loaded 5-Fu Microspheres |
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| Liu Qiuxiang,Zeng Lintao,Liang Yan,Qin Caiqin.Preparation and Characterization of Chitosan-loaded 5-Fu Microspheres[J].JOURNAL OF XIAOGAN UNIVERSITY,2007,27(3):5-8. | |
| Authors: | Liu Qiuxiang Zeng Lintao Liang Yan Qin Caiqin |
| Institution: | 1. College of Chemistry and Materials, China University of Geosciences, Wuhan, Hubei 430074, China; 2. Department of Chemistry, Xiaogan University, Xiaogan , Hubei 432000, China |
| Abstract: | The antitumor drugs 5-Fu-CS nanoparticles have been formed based on ionic gelation process of tripolyphosphate(TPP),5-Fu and chitosan.In order to gain the best parameters for preparing nanoparticles,the influences of different factors on average drug loading efficiency and particle size were evaluated by single-factor designing method.The physicochemical properties of nanoparticles were investigated in detail by using FTIR,UV Vis spectra,and laser dynamic scattering analysis.The average drug loading efficiency was 47.1% and the mean particle size was 143~212 nm.The release characteristics of the nanoparticles were studied in phosphate buffer solution.The results indicate that chitosan may be useful as a carrier for sustained release of drugs. |
| Keywords: | 5-Fluorouracil chitosan tripolyphosphate nanoparticles sustained release |
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