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The Collaborative Cross, a community resource for the genetic analysis of complex traits |
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| Authors: | Churchill Gary A Airey David C Allayee Hooman Angel Joe M Attie Alan D Beatty Jackson Beavis William D Belknap John K Bennett Beth Berrettini Wade Bleich Andre Bogue Molly Broman Karl W Buck Kari J Buckler Ed Burmeister Margit Chesler Elissa J Cheverud James M Clapcote Steven Cook Melloni N Cox Roger D Crabbe John C Crusio Wim E Darvasi Ariel Deschepper Christian F Doerge R W Farber Charles R Forejt Jiri Gaile Daniel Garlow Steven J Geiger Hartmut Gershenfeld Howard Gordon Terry Gu Jing Gu Weikuan de Haan Gerald Hayes Nancy L Heller Craig Himmelbauer Heinz Hitzemann Robert Hunter Kent |
| Institution: | The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA. garyc@jax.org |
| Abstract: | The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease. |
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