| 盐酸洛美沙星盐水注射液急性毒性试验研究 |
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| 引用本文： | 李冰,罗基花,孙弘霞,候风霞,管秀梅.盐酸洛美沙星盐水注射液急性毒性试验研究[J].北华大学学报(自然科学版),1998(1). |
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| 作者姓名： | 李冰 罗基花 孙弘霞 候风霞 管秀梅 |
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| 作者单位： | 吉林医学院生理教研室!吉林132001(李冰，罗基花，孙弘霞)，昌邑区卫生进修学校(候风霞)，吉林市中心医院(管秀梅) |
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| 摘 要： | 目的：研究盐酸洛美沙星的急性毒性。方法：参照药理实验方法学的方法测定其ＬＤ５０，１００只昆明小鼠随机分为５组尾静脉注射给药，观测４８小时内每组小鼠死亡数。结果：盐酸洛美沙星雌性小鼠组，ＬＤ５０＝２５５．３ｍｇ／ｋｇ；雄性小鼠ＬＤ５０＝２５１．２ｍｇ／ｋｇ，与盐酸洛美沙星葡萄糖注射液相比（ＬＤ５０＝２６１．２ｍｇ／ｋｇ）无明显差异。结论：盐酸洛美沙星盐水注射液与其葡萄糖液类似。
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| 关 键 词： | 盐酸洛美沙星 LD_(50) |
An acute toxicological experiment on saline injection of Lomefloxacin hydrochloride |
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| Li Bing,Luo Jihua,Sun Hongxia,Hou Fengxia,Jian Xiangmei.An acute toxicological experiment on saline injection of Lomefloxacin hydrochloride[J].Journal of Beihua University(Natural Science),1998(1). |
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| Authors: | Li Bing Luo Jihua Sun Hongxia Hou Fengxia Jian Xiangmei |
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| Abstract: | Objective: To study the acute toxicity of saline injection of Lomefloxacin hydrochloride. Rcsults: For female mice, LD50 of saline injection of Lomefloxacin hydrochloride=255.3mg/kg; for male mice LD50=251.2mg/kg. There was no significant difference as compared with the LD50 of glucose solution of Lomefloxacin hydrochioride Conclusion:The LD50 of saline of Lomefloxacin hydrochloride (LD50=261.2mg/kg). similar to the LD50of its glucose injection. |
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| Keywords: | Lomefloxacin hydrochloride LD50 |
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