Tricyclic antidepressants antagonize prostaglandin (PG) E20induced contractions of the guinea pig ileum and hypomotility in the mouse |
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| Authors: | Dr Fola M. Tayo |
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| Affiliation: | (1) Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, (Nigeria);(2) Department of Pharmacology, University of Vermont Medical College, Given Building, 05405 Burlington, Vt, USA |
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| Abstract: | ![]()
Summary The interactions of PGE2 and 2 tricyclic antidepressants were tested both on the guinea pig ileum and motility in the mouse. PGE2-induced contractions of the guinea pig ileum were irreversibly blocked by amitriptyline and desipramine. Chronic administration of amitriptyline and desipramine blocked PGE2-induced hypomotility in the mouse. |
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| Keywords: | PGE2 contraction hypomotility tricyclics |
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