NADP-isocitric dehydrogenase of gerbil adrenal mitochondria: Support of steroid hydroxylation |
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| Authors: | J. L. McCarthy J. Gauthier |
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| Affiliation: | (1) Department of Biology, Southern Methodist University, 75275 Dallas, Texas, USA |
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| Abstract: | Summary In gerbil adrenal cortex the activity of intramitochondrial NADP-linked isocitric dehydrogenase (IDH) is up to 10-fold greater than the NAD-linked IDH. The NADP-IDH, apparent Km 0.58 mM, Vmax 280 nmoles/min/mg mitochondrial protein, appears to be the major source of reducing equivalents to support adrenal mitochondrial steroid 11B- and 19-hydroxylation in this species. |
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| Keywords: | Gerbil adrenal cortex isocitric dehydrogenase mitochondria steroid steroid hydroxylation |
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