3D打印制备HA/PCL复合材料组织工程支架的研究

应用熔融沉积成型技术（FDM）制备羟基磷灰石（HA）/聚己内酯（PCL）组织工程支架，探讨其内部结构和力学性能。以羟基磷灰石和聚己内酯为原料，采用熔融共混技术分别制备HA质量分数为20%的nano-HA/PCL和micro-HA/PCL复合材料，使用自主研发的熔体微分FDM 3D打印机制备HA/PCL复合材料组织工程支架。通过显微镜观察发现，所制备的nano-HA/PCL和micro-HA/PCL组织工程支架具有均匀分布且相互连通的近似矩形的孔隙。nano-HA/PCL和micro-HA/PCL组织工程支架的断面图分析结果表明，nano-HA/PCL组织工程支架中HA粒子分布均匀，而micro-HA/PCL组织工程支架中HA粒子发生了团聚，导致nano-HA/PCL组织工程支架的拉伸强度和弯曲强度均高于micro-HA/PCL组织工程支架。因此，利用熔体微分FDM 3D打印机打印生物活性nano-HA/PCL复合材料组织工程支架在骨组织工程中具有潜在的应用前景。

Preparation of hydroxyapatite/polycaprolactone (HA/PCL) composite tissue engineering scaffolds by 3D printing

Hydroxyapatite/polycaprolactone (HA/PCL) scaffolds have been prepared by a fused deposition modeling (FDM) technique using hydroxyapatite (HA) and polycaprolactone (PCL) as raw materials and their internal structure and mechanical properties were explored in detail. Nano-HA/PCL and micro-HA/PCL composites with 20 wt.% HA were prepared by melt blending technology and, furthermore, HA/PCL composite tissue engineering scaffolds were prepared using a self-developed melt differential FDM 3D printer. By microscopic observations, it was found that the prepared nano-HA/PCL and micro-HA/PCL tissue engineering scaffolds have uniformly distributed and interconnected nearly rectangular pores. By observing the cross-sectional view of the nano-HA/PCL scaffold and the micro-HA/PCL scaffold, it can be seen that the HA particles in the nano-HA/PCL scaffold are evenly distributed and the HA particles in the micro-HA/PCL scaffold are agglomerated, which contributes to the nano-HA/PCL scaffolds having higher tensile strength and flexural strength than the micro-HA/PCL scaffolds. Therefore, the bio-active nano-HA/PCL composite scaffolds prepared using melt differential FDM 3D printers have better potential application prospects in bone tissue engineering.