Pathway-based analysis for genome-wide association studies of schizophrenia to provide new insight in schizophrenia study |
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| Authors: | KunLin Zhang LiuYan Zhang WeiNa Zhang Jing Wang |
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| Institution: | ZHANG KunLin 1,ZHANG LiuYan 1,2,ZHANG WeiNa 1,2 & WANG Jing 1* 1 Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China,2 Graduate University of Chinese Academy of Sciences,Beijing 100049 |
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| Abstract: | Schizophrenia (SZ) is an inheritable complex mental disease. There have been several genome-wide association studies (GWASs) of SZ to identify novel genetic susceptibility factors. To further interpret SZ GWASs, pathway-based analysis (PBA), which considers the combined effect of variants and identifies pathways associated with traits, provides a feasible solution to discover the biological function and mechanism of SZ. Furthermore, to investigate the common pathways between SZ and bipolar disorder (BD) wil... |
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| Keywords: | schizophrenia (SZ) genome-wide association study (GWAS) pathway-based analysis (PBA) bipolar disorder (BD) |
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