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Statistical issues and approaches in endophenotype research |
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| Authors: | Pak Chung Sham Stacey S Cherny Mei-Hua Hall |
| Institution: | SHAM Pak Chung 1*,CHERNY Stacey S 1 & HALL Mei-Hua 2 1 Department of Psychiatry and The State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong,Hong Kong,China,2 Psychology Research Laboratory,McLean Hospital,Harvard Medical School,Boston,MA 02115-6092,USA |
| Abstract: | The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic co... |
| Keywords: | psychiatric disorders endophenotypes genetics genomics association linkage |
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