| 酶法手性拆分技术研究和应用的最新进展 |
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| 引用本文： | 张国艳,曹淑桂.酶法手性拆分技术研究和应用的最新进展[J].吉林大学学报(理学版),2008,46(5):997-1000. |
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| 作者姓名： | 张国艳 曹淑桂 |
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| 作者单位： | 1. 吉林大学 分子酶学工程教育部重点实验室, 长春 130021; 2. 吉林大学 化学学院, 长春 130021 |
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| 基金项目： | 国家自然科学基金，中国博士后科学基金 |
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| 摘 要： | 系统地综述了酶法手性拆分技术的最新研究和应用进展， 对动力学拆分、 动态动力学拆分和对映体收敛转化3种方法进行了比较， 并介绍了酶，尤其是脂肪酶在非水介质中催化酯和氨基化合物的立体选择性水解、 转酯化和酰胺化的研究进展及其在技术上遇到的问题和解决方法.
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| 关 键 词： | 手性拆分 动力学拆分 动态动力学拆分 对映体收敛转化 |
| 收稿时间： | 2007-09-14 |
The Newly Development of the Enzyme-catalyzed Resolution Methods and Application |
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| ZHANG Guo-yan,CAO Shu-gui.The Newly Development of the Enzyme-catalyzed Resolution Methods and Application[J].Journal of Jilin University: Sci Ed,2008,46(5):997-1000. |
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| Authors: | ZHANG Guo-yan CAO Shu-gui |
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| Institution: | 1. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, Jilin University,Changchun 130021, China; 2. College of Chemistry, Jilin University, Changchun 130021, China |
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| Abstract: | The present paper described the recent research and application of chiral resolution by enzyme catalysis.The methods of kinetic resolution,dynamic kinetic resolution and enantioconvergence resolution were compared with each other.The steoroselective hydrolysis,transesterification and acylation of esters and amines catalyzed by enzymes,in particular,hydrolases in non-aqueous solution were also introduced according to the progress of research and the problems of technology. |
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| Keywords: | chiral resolution kinetic resolution dynamic kinetic resolution enantioconvergence |
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