| 非天然氨基酸修饰蛋白质研究进展 |
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| 引用本文： | 杜方川,王芬,神应强,陈灿玉,王安明.非天然氨基酸修饰蛋白质研究进展[J].杭州师范学院学报(自然科学版),2013(5):437-445. |
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| 作者姓名： | 杜方川 王芬 神应强 陈灿玉 王安明 |
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| 作者单位： | [1]杭州师范大学生物医药与健康研究中心,浙江杭州311121 [2]杭州师范大学生命与环境科学学院,浙江杭州310036 [3]杭州师范大学材料与化学化工学院,浙江杭州310036 |
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| 基金项目： | 国家自然科学基金项目（20906016）; 浙江省自然科学基金项目（LY13B060008）.; 博士后特别资助项目（2013T60606） |
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| 摘 要： | 蛋白质修饰是改善其物理化学和生物学特性的一种重要方法,目前已成为生物技术、生物催化和生物医学领域的研究热点.非天然氨基酸在蛋白质修饰中表现突出.介绍了非天然氨基酸种类及修饰方法,概述了其应用领域,以期为扩大利用此方法者提供参考.
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| 关 键 词： | 生物正交反应 蛋白质修饰 非天然氨基酸 密码子扩展 |
On the Modification of Proteins by Unnatural Amino Acids |
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| DU Fangchuan＇＇,WANG Feng＇＇,SHENG Yingqiang,＇,CHEN Canyu,WANG Anming.On the Modification of Proteins by Unnatural Amino Acids[J].Journal of Hangzhou Teachers College(Natural Science),2013(5):437-445. |
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| Authors: | DU Fangchuan＇＇ WANG Feng＇＇ SHENG Yingqiang ＇ CHEN Canyu WANG Anming |
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| Institution: | 1 (1. Research Center of Biomedicine and Health, Hangzhou Normal University, Hangzhou 311121, China (2. College of Biological and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, China College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China) |
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| Abstract: | Protein modification is an important method for improving the physicochemieat and biological characteristics of protein, which has become a hotspot of bio-technology and bio-catalytic and biomedical field. The unnatural amino acids have an outstanding performance in the protein modification. This paper introduced the type of unnatural amino acid and modification methods, and summarized its application fields to provide references for espending the use of this method. |
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| Keywords: | bioorthogonal reactions protein modification unnatural amino acid codon extension |
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