肿瘤磁感应热疗用115kHz中频交变磁场对小鼠生殖系统的影响

 为了研究肿瘤磁感应热疗用115kHz中频交变磁场对精子密度、活动率、精子运动系数和睾丸重量的影响，以及观察睾丸组织病理变化，探讨中频交变磁场下生殖系统的生物学现象，采用115kHz中频磁场对Balb/C小鼠进行全身短期连续辐照（7d）和长期连续辐照（28d），辐照强度为12mT，时间为1h/d，分为对照组（0T）和辐照组（12mT），每组8只小鼠。辐照后取小鼠双侧睾丸称重、固定，并取附睾精子进行分析。结果表明，短期辐照可使睾丸重量增加，长期辐照可使精子密度、活动率增加，短期与长期辐照中频交变磁场对小鼠雄性生殖系统无损伤效应。由此可得，肿瘤磁感应热疗用115kHz中频交变磁场具有促进睾丸组织细胞增殖的作用，且无损伤效应。

Effects of a 115-kHz Intermediate Frequency Alternating Magnetic Field on the Reproductive System of Male Mice

Objective To assess the potential effect of intermediate frequency (IF) alternating magnetic field on reproductive system of experimental mice. Methods Male Balb/C mice (18-26 g) were randomly divided into four groups (n=8). Mice receiving radiation were exposed to the magnetic field (115 kHz, 10.5kA/m) for 1 hour per day for 7days (short-term exposure group) or 28 days (long-term exposure group). Each radiation group had a sham control counterpart. After treatment mice were sacrificed and testis, epididymal sperm were separated. Testicular weight, sperm density, sperm activity rate, and sperm motility were examined. Histopathological analysis of the testis was performed. Results The IF did not affect sperm activity of experimental mice. The testicular weights of short-term group were increased. The sperm density and sperm motility of long-term exposure group were increased. Conclusion There was no evidence of toxicity associated with exposure to the magnetic field of examined parameters. IF might promote testis cells proliferation.