| TNF与IFN协同诱导癌细胞凋亡机制的研究进展 |
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| 引用本文： | 关燕清,杨鑫华,何丽梅,彭仕娟,陈文晓,欧敏雅,钟炼敏,张荷花.TNF与IFN协同诱导癌细胞凋亡机制的研究进展[J].华南师范大学学报(自然科学版),2006,0(3):122-126. |
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| 作者姓名： | 关燕清 杨鑫华 何丽梅 彭仕娟 陈文晓 欧敏雅 钟炼敏 张荷花 |
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| 作者单位： | 华南师范大学生命科学学院,广东,广州,510631 |
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| 基金项目： | 教育部博士后基金资助项目(2004035588) |
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| 摘 要： | 综述了肿瘤坏死因子(TNF)与干扰素(IFN)协同诱导肿瘤细胞凋亡的机制.分别从受体、细胞周期、相关基因及凋亡途径4个方面进行阐述,以期为细胞因子的游离及固定药物的机制研究提供理论参考,并对肿瘤细胞因子治疗的临床用药有指导意义.
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| 关 键 词： | 肿瘤坏死因子 干扰素 协同作用 细胞凋亡 机制 |
| 文章编号： | 1000-5463（2006）03-0122-05 |
| 收稿时间： | 2006-03-14 |
| 修稿时间： | 2006年3月14日 |
RESEARCH PROGRESS OF SYNERGIC MECHANISMS OF APOPTOSIS INDUCED BY TNF AND IFN |
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| GUAN Yan-qing,YANG Xin-Hua,HE Li-mei,PENG Shi-juan,CHEN Wen-xiao,OU Min-yan,ZHONG Lian-min,ZHANG He-hua.RESEARCH PROGRESS OF SYNERGIC MECHANISMS OF APOPTOSIS INDUCED BY TNF AND IFN[J].Journal of South China Normal University(Natural Science Edition),2006,0(3):122-126. |
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| Authors: | GUAN Yan-qing YANG Xin-Hua HE Li-mei PENG Shi-juan CHEN Wen-xiao OU Min-yan ZHONG Lian-min ZHANG He-hua |
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| Institution: | School of Life Science, South China Normal University, Guangzhou 510631, China |
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| Abstract: | It is presented the synergic mechanisms of tumor apoptosis induced by Tumor-necrosis factor(TNF) along with Interferon(IFN) in terms of receptors,cell cycle,relevant genes as well as approaches of induction,in order to review the difference between the mechanisms of dissociated and immobilized cell factors which will be extremely significant for the usage of anti-tumor cell factors in clinic treatment. |
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| Keywords: | tumor necrosis factor interferon synergy apoptosis mechanism(s) |
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