Comparison of the effects of different isomers of bicuculline infused in the preoptic area on male rat sexual behavior |
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| Authors: | A Fernández-Guasti K Larsson C Beyer |
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| Institution: | (1) Department of Psychology, Unit of Psychobiology, University of Göteborg, Box 14158, S-400 20 Göteborg, (Sweden);(2) Centro de Investigación en Reproducción Animal, CINVESTAV-UAT, Ap. Postal 62, 90-000 Tlaxcala, (México) |
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| Abstract: | Summary Intracerebral infusion of (+) bicuculline methiodide, but not of its (–) isomer, in the preoptic area, stimulated masculine sexual behavior in rat as evidenced by a decrease in the number of intromissions preceding ejaculation and a shortening of the ejaculation latency and postejaculatory interval. Data suggest a role of the GABAergic system in mediating masculine sexual behavior.Acknowledgments. Authors wish to thank Ms Elisabeth Wallin for excellent technical assistance and Ms Madelene Kröning for preparing the figures. |
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| Keywords: | (+) and (– ) bicuculline methiodide masculine sexual behavior preoptic-anterior hypothalamic area rat |
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