Effect of prostaglandins and dibutyryl cyclic AMP on the morphology of cells in primary astroglial cultures and on metabolic enzymes of GABA and glutamate metabolism |
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| Authors: | M Tardy C Fages B Rolland J Bardakdjian P Gonnard |
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| Institution: | (1) Département de Biochimie, C. H. U. Henri-Mondor, 51, Avenue de Lattre-de-Tassigny, F-94010 Créteil Cédex, France |
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| Abstract: | Summary Prostaglandins (PGE1) and dibutyryl cyclic AMP (dBc AMP) induce similar morphological changes in astrocytes obtained in primary cultures. PGE1 and dBc AMP increased 2 enzymes of GABA and glutamate metabolism, GABA-T and AAT, but did not modify GDH and GLN-S. Prostaglandins probably affect the cAMP content of glial cells and act in the same way as dBc AMP on glial cell differentiation. |
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