| 半胱胺对小鼠抗氧化能力的影响 |
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| 引用本文： | 刘华忠,钟杰平.半胱胺对小鼠抗氧化能力的影响[J].河南科技大学学报(自然科学版),2009,30(1). |
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| 作者姓名： | 刘华忠 钟杰平 |
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| 作者单位： | 广东海洋大学,现代生物化学中心,广东,湛江,524088 |
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| 基金项目： | 国家自然科学基金，广东海洋大学自然科学基金 |
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| 摘 要： | 探索半胱胺(Cysteamine,CS)对小鼠抗氧化能力的影响,按50 mg/kg和100 mg/kg 体重半胱胺盐的配比浓度灌服小鼠,采用试剂盒分别检测血浆、肝脏和大脑中超氧化物歧化酶、丙二醛和谷胱甘肽过氧化物酶水平.结果显示:SOD水平在三种组织器官中,均出现明显升高,而谷胱甘肽过氧化物酶只在血浆中含量发生了明显的上升变化,肝脏和大脑中无影响;至于丙二醛这种脂质过氧化的产物,在三种组织器官中均呈现相似的变化规律,其含量显著性降低.以上结果表明:CS能改善小鼠抗氧化指标水平,增强机体的抗氧化能力.
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| 关 键 词： | 半胱胺 抗氧化 小鼠 |
Effects of Cysteamine on Antioxidant Ability of Mice |
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| LIU Hua-Zhong,ZHONG Jie-Ping.Effects of Cysteamine on Antioxidant Ability of Mice[J].Journal of Henan University of Science & Technology:Natural Science,2009,30(1). |
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| Authors: | LIU Hua-Zhong ZHONG Jie-Ping |
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| Institution: | Modern Biochemistry Center;Guangdong Ocean University;Zhanjiang 524088;China |
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| Abstract: | To investigate the effects of cysteamine on antioxidant ability of mice,mice were orally administrated with 50 mg/kg body weight cysteamine hydrochloride and 100 mg/kg body weight cysteamine hydrochloride respectively.Kits were used to detect the level of MDA and activities of SOD and GSH-Px in plasma,liver and brain from mice.Results showed that CS increased significantly levels of SOD in three tissues or organs,upregulated obviously activity of GSH-Px in plasma but did not modify activity of GSH-Px in liv... |
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| Keywords: | Cysteamine Antioxidation Mice |
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