| 人血清白蛋白与叶酸相互作用的荧光光谱法研究 |
| |
| 引用本文： | 白海鑫,刘小花,袁超. 人血清白蛋白与叶酸相互作用的荧光光谱法研究[J]. 河南科学, 2008, 26(12) |
| |
| 作者姓名： | 白海鑫 刘小花 袁超 |
| |
| 作者单位： | 河南农业大学,理学院,郑州,450002;河南农业大学,理学院,郑州,450002;河南农业大学,理学院,郑州,450002 |
| |
| 基金项目： | 河南农业大学博士科研启动基金项目 |
| |
| 摘 要： | 基于荧光光谱技术,研究了人血清白蛋白与叶酸的相互作用.结果表明:人血清白蛋白与叶酸共存时会发生相互作用;叶酸对人血清白蛋白荧光光淬灭机制为静态淬灭,且在发生荧光淬灭的同时生成了蛋白质与药物的复合物;人血清白蛋白是通过疏水性作用力与叶酸发生相互作用的,叶酸在血清白蛋白中仅有一个结合位点.
|
| 关 键 词： | 人血清白蛋白 叶酸 相互作用 荧光光谱法 |
The Studies on the Interaction of Human Serum Albumin with Folic Acid by the Fluorescence Spectroscopic Methods |
| |
| Bai Haixin,Liu Xiaohua,Yuan Chao. The Studies on the Interaction of Human Serum Albumin with Folic Acid by the Fluorescence Spectroscopic Methods[J]. Henan Science, 2008, 26(12) |
| |
| Authors: | Bai Haixin Liu Xiaohua Yuan Chao |
| |
| Affiliation: | Bai Haixin,Liu Xiaohua,Yuan Chao(College of Sciences,Henan Agricultural University,Zhengzhou 450002,China) |
| |
| Abstract: | The interaction of bovine serum albumin with folic acid was studied based on the fluorescence spectroscopic methods. The results indicated that human serum albumin interacted with folic acid as they coexisted,and they formed into protein-drug complex by the static quenching of human serum albumin by folic acid. The results also showed that the human serum albumin interacted with folic acid by hydrophobic association,and there was one binding-site for folic acid in the molecule of human serum albumin as they... |
| |
| Keywords: | human serum albumin folic acid interaction fluorescence spectroscopic methods |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
