Effect of thiamine hydrochloride on the blood level of 2-formyl 1-methyl pyridinium oxime chloride (2-PAM.Cl) in rats

Summary The biological half-life of 2-PAM.Cl was found to increase in female rats pretreated with thiamine hydrochloride (10 mg/kg i.m.). No such effect was observed in the male rats.Dr B.L. Chowdhri very kindly synthesized the compound 2-PAM.Cl in the Department of Chemistry of this establishment for this work.The authors are thankful to Dr P.K. Ramachandran, Director, and Dr A.K. Chatterjee, Deputy Director, Defence Research and Development Establishment, Gwalior, for their keen interest in this work.