| N,S-配体协助下钯催化的Suzuki-Miyaura交叉偶联反应 |
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| 引用本文： | 张占金,田瑜,黄修鹏,屈苗,梁群,陈会英. N,S-配体协助下钯催化的Suzuki-Miyaura交叉偶联反应[J]. 大连民族学院学报, 2017, 19(5): 433-437 |
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| 作者姓名： | 张占金 田瑜 黄修鹏 屈苗 梁群 陈会英 |
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| 作者单位： | 大连民族大学 生命科学学院,辽宁 大连 116605 |
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| 摘 要： | 以廉价、易得的芳(杂环)甲醛、取代肼及羟胺等为原料,合成了9种N,N-、N,O-、N,S-腙及肟配体,并在相对温和的反应条件下,将其应用到了钯催化的Suzuki-Miyaura交叉偶联反应中,开发了一种温和、高效的以腙为配体的钯催化系统Pd(OAc)2/2-噻吩甲醛苯腙(4b)/K3PO4/DMSO。将该系统用于催化苯硼酸与芳溴的交叉偶联反应中,得到了良好的分离收率。
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| 关 键 词： | 芳(杂环)甲醛 腙配体 苯硼酸 芳基溴 Suzuki-Miyaura交叉偶联反应 |
Palladium-Catalyzed Suzuki-Miyaura Cross Coupling UsingN,S-Hydrazone as Ligand |
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| ZHANG Zhan-jin,TIAN Yu,HUANG Xiu-peng,QU Miao,LIANG Qun,CHEN Hui-ying. Palladium-Catalyzed Suzuki-Miyaura Cross Coupling UsingN,S-Hydrazone as Ligand[J]. Journal of Dalian Nationalities University, 2017, 19(5): 433-437 |
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| Authors: | ZHANG Zhan-jin TIAN Yu HUANG Xiu-peng QU Miao LIANG Qun CHEN Hui-ying |
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| Affiliation: | School of Life Science, Dalian Minzu University, Dalian Liaoning 116605, China |
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| Abstract: | Nine N,N-, N,O-, N,S- ligands of hydrazone and oxime were synthesized through inexpensive and available aryl(heterocyclic) formaldehyde, substitutional hydrazine and azanol. The ligands were applied to Suzuki-Miyaura coupling catalyzed by palladium under moderate reaction conditions. A mild and highly efficient palladium-catalyzed system Pd(OAc)2/2-thiophene formaldehyde hydrazone (4b)/K3PO4/DMSO for cross coupling reaction of aryl boric acid with aryl halides using hydrazone as ligand was developed and the good yields were obtained. |
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| Keywords: | aryl(heterocyclic) formaldehyde hydrazone ligand phenyloboric acid aryl bromide Suzuki-Miyaura cross coupling |
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