| 1,2,3-三氮唑衍生物的合成及其抑制幽门螺杆菌活性研究 |
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| 引用本文： | 吴凤艳,陈昌红,彭立望. 1,2,3-三氮唑衍生物的合成及其抑制幽门螺杆菌活性研究[J]. 邵阳学院学报(自然科学版), 2011, 8(3): 58-62 |
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| 作者姓名： | 吴凤艳 陈昌红 彭立望 |
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| 作者单位： | 邵阳学院生物与化学工程系,湖南邵阳,422000 |
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| 基金项目： | 湖南省大学生研究性学习和创新性实验计划项目资助 |
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| 摘 要： | 设计并合成了15个未曾见文献报道的1-(2-(4-取代)苯氧乙基)-1H-1,2,3-三氮唑衍生物,并通过NMR、IR、MS确认了它们的结构.对合成条件进行了探讨,得出了叠氮化的最佳合成条件:卤代烃/叠氮化钠摩尔比为1:1.5,反应温度为65℃,幽门螺旋杆菌(HP)体外抑制活性测试结果表明,化合物4c、5d、5k、5l对1 6株HP表现出一定的抑制活性.
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| 关 键 词： | 1,2,3-三氮唑 合成 幽门螺旋杆菌 |
Studies on the Synthesis and Anti-Helicobacter Pylori Activity of 1,2,3-Triazole Derivatives |
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| WU Feng-yan,CHEN Chang-hong,PENG Li-wang. Studies on the Synthesis and Anti-Helicobacter Pylori Activity of 1,2,3-Triazole Derivatives[J]. Journal of Shaoyang University(Natural Science Edition), 2011, 8(3): 58-62 |
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| Authors: | WU Feng-yan CHEN Chang-hong PENG Li-wang |
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| Affiliation: | WU Feng-yan,CHEN Chang-hong,PENG Li-wang (Department of Biological and Chemical Engineering,Shaoyang University,Shaoyang,Hunan 422000,china) |
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| Abstract: | Fifteen unknown 1-（2-（4-subsitituted）phenyloxyethyl）-1,2,3-triazole derivatives winthout recorded report were synthesized,their structures were confirmed by NMR,IR,and MS.Synthetic conditions were discussed,the optimum reaction conditions were obtained as follows： n（RX）：n（NaN3）=1：3,reaction temperature 65℃.The preliminary results against Helicobacter pylori（HP） indicated that four compounds 4c,5d,5k and 5l could show a high antibacterial activity against HP. |
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| Keywords: | 1 2 3-triazole synthesis helicobacter pylori |
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